Lung cancer increases H2O2 concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa.
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ABSTRACT:
SUBMITTER: Kolbasina NA
PROVIDER: S-EPMC7327746 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Lung cancer increases H<sub>2</sub>O<sub>2</sub> concentration in the exhaled breath condensate, extent of mtDNA damage, and mtDNA copy number in buccal mucosa.
Kolbasina Natalya A NA Gureev Artem P AP Serzhantova Olga V OV Mikhailov Andrey A AA Moshurov Ivan P IP Starkov Anatoly A AA Popov Vasily N VN
Heliyon 20200628 6
We have shown that the H<sub>2</sub>O<sub>2</sub> concentration in exhaled breath condensate (EBC) in lung cancer patients increases significantly compared to the EBC of healthy people and revealed the correlation between the H<sub>2</sub>O<sub>2</sub> level in the EBC and amount of mtDNA damage in buccal mucosa cells. The H<sub>2</sub>O<sub>2</sub> hyper-production may trigger mitochondrial biogenesis, thereby resulting in an increase in mtDNA copy number. However, we did not observe a signific ...[more]
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