A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction.

ABSTRACT: The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular membranes. As a consequence, in many cell types, perturbing this balance alters crucial cellular processes, such as vesicular budding and the trafficking/function of membrane-anchored proteins. The worldwide spread of the Western diet, which is highly enriched in saturated fats, has been clearly correlated with the emergence of a complex syndrome known as metabolic syndrome (MetS). MetS is defined as a cluster of risk factors for cardiovascular diseases, type 2 diabetes and hepatic steatosis; however, no clear correlations have been established between diet-induced fatty acid redistribution within cellular PLs an

SUBMITTER: Bacle A 

PROVIDER: S-EPMC7328154 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature