Epigenetic Factors That Control Pericentric Heterochromatin Organization in Mammals.

ABSTRACT: Pericentric heterochromatin (PCH) is a particular form of constitutive heterochromatin that is localized to both sides of centromeres and that forms silent compartments enriched in repressive marks. These genomic regions contain species-specific repetitive satellite DNA that differs in terms of nucleotide sequences and repeat lengths. In spite of this sequence diversity, PCH is involved in many biological phenomena that are conserved among species, including centromere function, the preservation of genome integrity, the suppression of spurious recombination during meiosis, and the organization of genomic silent compartments in the nucleus. PCH organization and maintenance of its repressive state is tightly regulated by a plethora of factors, including enzymes (e.g., DNA methyltransferases,

SUBMITTER: Fioriniello S 

PROVIDER: S-EPMC7349813 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature