Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway.

ABSTRACT: The alarm cytokine interleukin-1β (IL-1β) is a potent activator of the inflammatory cascade following pathogen recognition. IL-1β production typically requires two signals: first, priming by recognition of pathogen-associated molecular patterns leads to the production of immature pro-IL-1β; subsequently, inflammasome activation by a secondary signal allows cleavage and maturation of IL-1β from its pro-form. However, despite the important role of IL-1β in controlling local and systemic inflammation, its overall regulation is still not fully understood. Here we demonstrate that peritoneal tissue-resident macrophages use an active inhibitory pathway, to suppress IL-1β processing, which can otherwise occur in the absence of a second signal. Programming by the transcription factor Gata6 control

SUBMITTER: Ipseiz N 

PROVIDER: S-EPMC7360975 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature