Interleukin 15 upregulates the expression of PD-1 and TIM-3 on CD4⁺ and CD8⁺ T cells.

ABSTRACT: Virus-specific T cell-mediated immunity is severely impaired in chronic hepatitis B virus (HBV) patients. HBV-specific T cells in chronic HBV patients show a low ability to produce cytokines and to exert their cytotoxic activity. A prominent characteristic of these exhausted T cells is overexpression of inhibitory receptor molecules which negatively regulate T cell function. In this study, we examined in vitro regulation of two inhibitory receptor expressions, programmed death 1 (PD-1) and T cell immunoglobulin mucin domain-containing molecule 3 (TIM-3). Peripheral blood mononuclear cells (PBMCs) obtained from healthy individuals were in vitro stimulated with a panel of cytokines. PD-1 and TIM-3 expression levels on CD4⁺ and CD8⁺ T cells were examined at

SUBMITTER: Hakim MS 

PROVIDER: S-EPMC7364376 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature