Impact of mitral regurgitation on cardiovascular hospitalization and death in newly diagnosed heart failure patients.

ABSTRACT:

Aims

Heart failure (HF) carries a poor prognosis, and the impact of concomitant mitral regurgitation (MR) is not well understood. This analysis aimed to estimate the incremental effect of MR in patients newly diagnosed with HF.

Methods and results

Data from the IBM® MarketScan® Research Databases were analysed. Included patients had at least one inpatient or two outpatient HF claims. A 6 month post-period after HF index was used to capture MR diagnosis and severity. HF patients were separated into three cohorts: without MR (no MR), not clinically significant MR (nsMR), and significant MR (sMR). Time-to-event analyses were modelled to estimate the clinical burden of disease. The primary outcome was a composite endpoint of death or cardiovascular (CV)-related admission. Second

SUBMITTER: Cork DP 

PROVIDER: S-EPMC7373926 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature