Costimulation Blockade Disrupts CD4⁺ T Cell Memory Pathways and Uncouples Their Link to Decline in β-Cell Function in Type 1 Diabetes.

ABSTRACT: We previously reported that costimulation blockade by abatacept limits the decline of β-cell function and the frequency of circulating CD4⁺ central memory T cells (T_CM) (CD45RO⁺CD62L⁺) in new-onset type 1 diabetes. In human subjects receiving placebo, we found a significant association between an increase in CD4⁺ T_CM cells and the decline of β-cell function. To extend and refine these findings, we examined changes in human CD4⁺ and CD8⁺ naive and memory T cell subsets at greater resolution using polychromatic flow and mass cytometry. In the placebo group, we successfully reproduced the original finding of a significant association between T_CM and β-cell function and extended this to other T c

SUBMITTER: Eichmann M 

PROVIDER: S-EPMC7378361 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature