GFR Estimation Using a Panel of Filtration Markers in Shanghai and Beijing.

ABSTRACT:

Rationale & objectives

Estimated glomerular filtration rate (eGFR) using creatinine and cystatin C (eGFR_cr-cys) may be less accurate compared to measured GFR (mGFR) in China than in North America, Europe, and Australia due to variation across regions in their non-GFR determinants. The non-GFR determinants of β₂-microglobulin (B2M) and β-trace protein (BTP) differ from those of creatinine and cystatin C. Thus, the average eGFR using all 4 markers (eGFR_avg) could be more accurate than eGFR_cr-cys in China.

Study design

Diagnostic test study.

Setting & participants

1,066 participants in Shanghai and Beijing with creatinine and cystatin C and 666 participants with all 4 filtration markers.

Tests compared

Index tests were p

SUBMITTER: Chen N 

PROVIDER: S-EPMC7380432 | biostudies-literature | 2020 Mar-Apr

REPOSITORIES: biostudies-literature