Serum soluble urokinase plasminogen activator receptor in adolescents: interaction of chronic pain and obesity.

ABSTRACT:

Introduction

Obesity in adolescents is increasing in frequency and is associated with short-term and long-term negative consequences that include the exacerbation of co-occurring chronic pain.

Objective

To determine whether the interaction between chronic pain and obesity would be reflected in changes in serum soluble urokinase plasminogen activator receptor (suPAR) concentrations, a novel marker of systemic inflammation associated with obesity, insulin resistance, and cardiovascular disease.

Methods

We measured serum suPAR levels in 146 adolescent males and females with no pain or obesity (healthy controls; n = 40), chronic pain with healthy weight (n = 37), obesity alone (n = 41), and the combination of chronic pain and obesity (n = 28).

Results

Serum suPAR (

SUBMITTER: Raff H 

PROVIDER: S-EPMC7382552 | biostudies-literature | 2020 Jul-Aug

REPOSITORIES: biostudies-literature