Longitudinal Changes in Kidney Function Estimated from Cystatin C and Its Association with Mortality in Elderly Women.

ABSTRACT:

Background/aims

Prospective data on age-related changes in kidney function are required, especially since the current Kidney Disease Improving Global Outcomes (KDIGO) definition has been suggested to classify a large number of elderly people with CKD.

Objective

This study, a complement to our previous Cr-based study in the same cohort, is aimed at evaluating cystatin C (cysC)-based changes in kidney function during aging in older women and analyzing the association between CKD and mortality through 10 years of follow-up.

Methods

cysC was available in 981 women from the Osteoporosis Prospective Risk Assessment (OPRA) cohort, all aged 75 years on entry. Reinvestigations were made after 5 (n = 685) and 10 years (n = 365). Kidney function was estimated (estimated glomerul

SUBMITTER: Malmgren L 

PROVIDER: S-EPMC7384338 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature