Dataset Information
Lack of associations between lactoferrin (LTF) and mannose-binding lectin 2 (MBL2) gene polymorphism and dental caries susceptibility.
Ontology highlight
ABSTRACT: Objective
With the development of human genomics, the genetic factors associated with dental caries have receiving increasing attention. This study was performed to evaluate the relationship between lactoferrin (LTF) and mannose-binding lectin 2 (MBL2) gene single nucleotide polymorphisms (SNPs) and dental caries susceptibility in Chinese children.Methods
This prospective case-control study included 360 unrelated children (aged 12-15 years) who received oral health examinations and questionnaire surveys. The children were divided into two groups by counting the numbers of decayed, missing, and filled teeth (DMFT/dmft): case group (n = 162, DMFT/dmft ≥ 1) and control group (n = 198, DMFT/dmft = 0); non-invasive saliva samples were collected to extract genomic DNA. Six SNPs (rs2073495C/G, rs1042073C/T, rs10865941C/T, and rs1126477A/G in LTF; rs7096206C/G and rs7095891G/A in MBL2) were tested by mass spectrometry.Results
The study included 360 individuals with (85 boys and 77 girls) and without a history of caries (96 boys and 102 girls). There were no statistically significant differences in alleles and genotypes among the six SNPs between the two groups.Conclusion
There is no evidence that polymorphisms of LTF and MBL2 genes are associated with dental caries susceptibility in populations from northwest China; further confirmation is needed with larger sample sizes.
SUBMITTER: Hu XP
PROVIDER: S-EPMC7388124 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Lack of associations between lactoferrin (<i>LTF</i>) and mannose-binding lectin 2 (<i>MBL2</i>) gene polymorphism and dental caries susceptibility.
The Journal of international medical research 20200701 7
<h4>Objective</h4>With the development of human genomics, the genetic factors associated with dental caries have receiving increasing attention. This study was performed to evaluate the relationship between lactoferrin (<i>LTF</i>) and mannose-binding lectin 2 (<i>MBL2</i>) gene single nucleotide polymorphisms (SNPs) and dental caries susceptibility in Chinese children.<h4>Methods</h4>This prospective case-control study included 360 unrelated children (aged 12-15 years) who received oral health ...[more]