Ontology highlight
ABSTRACT:
SUBMITTER: Brunner N
PROVIDER: S-EPMC7396581 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Brunner Nora N Stein Laura L Cornelius Valeria V Knittel Ria R Fallier-Becker Petra P Amasheh Salah S
Frontiers in physiology 20200721
Claudin-5 determines the sealing properties of blood-brain barrier tight junctions and its function is impaired in neurodegenerative and neuroinflammatory disorders. Focusing on the contribution of claudin-5 to the <i>trans</i>-interaction within the tight junction seal, we used <i>Xenopus laevis</i> oocytes as an expression system. Cells were clustered and challenged in a novel approach for the analysis of claudin interaction. We evaluated the strengthening effect of claudin-5 to cell-cell-conn ...[more]