4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice.

ABSTRACT:

Introduction

We recently demonstrated the beneficial effects of 4-aminopyridine (4-AP), a potassium channel blocker, in enhancing remyelination and recovery of nerve conduction velocity and motor function after sciatic nerve crush injury in mice. Although muscle atrophy occurs very rapidly after nerve injury, the effect of 4-AP on muscle atrophy and intrinsic muscle contractile function is largely unknown.

Methods

Mice were assigned to sciatic nerve crush injury and no-injury groups and were followed for 3, 7, and 14 days with/without 4-AP or saline treatment. Morphological, functional, and transcriptional properties of skeletal muscle were assessed.

Results

In addition to improving in vivo function, 4-AP significantly reduced muscle atrophy with increased muscle fibe

SUBMITTER: Yue L 

PROVIDER: S-EPMC7397862 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature