Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney.

ABSTRACT: N-Methyl-d-aspartate receptor (NMDAR) is a glutamate-gated ionotropic receptor that intervenes in most of the excitatory synaptic transmission within the central nervous system (CNS). Aside from being broadly distributed in the CNS and having indispensable functions in the brain, NMDAR has predominant roles in many physiological and pathological processes in a wide range of non-neuronal cells and tissues. The present review outlines current knowledge and understanding of the physiological and pathophysiological functions of NMDAR in the kidney, an essential excretory and endocrine organ responsible for the whole-body homeostasis. The review also explores the recent findings regarding signaling pathways involved in NMDAR-mediated responses in the kidney. As established from diverse lines of

SUBMITTER: Valdivielso JM 

PROVIDER: S-EPMC7407907 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature