Gene expression analysis of primary gingival cancer by whole exome sequencing in thirteen Chinese patients.

ABSTRACT: OBJECTIVES:Early diagnosis of and markers for gingival oral squamous cell carcinoma (OSCC) is important for effective treatment. METHODS:The current study performed a whole exome sequencing of gingival OSCC tissues in thirteen Chinese patients to explore exonic mutants. RESULTS:Eighty-five genes emerged as mutants in patients with primary gingival OSCC. CCL4L1 presented a G>A transversion at chr17 17q12, position 36212480, exon 3. KDM5B presented a T>TA insertion at chr1 1q32.1, position 202766506, exon 6. ANKRD36C presented a C>G transition at chr2 2q11.1, position 95945175, exon 18. CONCLUSION:These three mutants might be new markers of gingival OSCC. The finding may provide new targets to diagnose and treat gingival OSCC.

SUBMITTER: Liu GM 

PROVIDER: S-EPMC7414513 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature