Anterior insular network disconnection and cognitive impairment in Parkinson's disease.

ABSTRACT:

Background

The insula is a central brain hub involved in cognition and affected in Parkinson's disease (PD). The aim of this study was to assess functional connectivity (FC) and betweenness centrality (BC) of insular sub-regions and their relationship with cognitive impairment in PD.

Methods

Whole-brain 3D-T1, resting-state functional MRI and a battery of cognitive tests (CAMCOG) were included for 53 PD patients and 15 controls. The insular cortex was segmented into ventral (vAI) and dorsal (dAI) anterior and posterior sub-regions. Connectivity between insular sub-regions and resting-state networks was assessed and related to cognition; BC was used to further explore nodes associated with cognition.

Results

Cognitive performance was significantly lower in PD patients

SUBMITTER: Fathy YY 

PROVIDER: S-EPMC7417948 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature