Ontology highlight
ABSTRACT:
SUBMITTER: Sarikhani M
PROVIDER: S-EPMC7419706 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Sarikhani Mohsen M Garbern Jessica C JC Ma Sai S Sereda Rebecca R Conde Jeffrey J Krähenbühl Guido G Escalante Gabriela O GO Ahmed Aishah A Buenrostro Jason D JD Lee Richard T RT
Stem cell reports 20200709 2
Recent studies suggest that metabolic regulation may improve differentiation of cardiomyocytes derived from induced pluripotent stem cells (iPSCs). AMP-activated protein kinase (AMPK) is a master regulator of metabolic activities. We investigated whether AMPK participates in iPSC-derived cardiomyocyte differentiation. We observed that AMPK phosphorylation at Thr172 increased at day 9 but then decreased after day 11 of differentiation to cardiomyocytes. Inhibition of AMPK with compound C signific ...[more]