Gene signature and prognostic merit of M6a regulators in colorectal cancer.
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ABSTRACT: Impact statement
Although new diagnostic techniques and treatments are increasingly updated for CRC, the clinical outcomes of CRC patients are still not encouraging with a low survival rate. N6-methyladenosine (m6A) as a popular modification on mRNA is associated with multiple types of cancers. Our purpose is to identify gene signature and prognostic ability of m6A modulators in CRC. For the first time, we identified genetic changes of m6A modulators and built prognostic gene signature in CRC, which may provide effective targets for the diagnosis and management of CRC.
SUBMITTER: Zhang J
PROVIDER: S-EPMC7441353 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Gene signature and prognostic merit of M6a regulators in colorectal cancer.
Zhang Jinfeng J Cheng Xuedi X Wang Junzheng J Huang Yongjie Y Yuan Junhui J Guo Dawen D
Experimental biology and medicine (Maywood, N.J.) 20200630 15
<h4>Impact statement</h4>Although new diagnostic techniques and treatments are increasingly updated for CRC, the clinical outcomes of CRC patients are still not encouraging with a low survival rate. N6-methyladenosine (m6A) as a popular modification on mRNA is associated with multiple types of cancers. Our purpose is to identify gene signature and prognostic ability of m6A modulators in CRC. For the first time, we identified genetic changes of m6A modulators and built prognostic gene signature i ...[more]
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