COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study.

ABSTRACT:

Background

A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-19-associated hyperinflammation (COV-HI), and its associations with escalation of respiratory support and survival.

Methods

In this retrospective cohort study, we enrolled consecutive inpatients (aged ≥18 years) admitted to University College London Hospitals and Newcastle upon Tyne Hospitals in the UK with PCR-confirmed COVID-19 during the first wave of community-acquired infection. Demographic data, laboratory tests, and clinical status were recorded from the day of admission until death or discharge, with a minimum follow-up time of 28 days. We defined COV-HI as a C-reactive protein

SUBMITTER: Manson JJ 

PROVIDER: S-EPMC7442426 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature