Peripheral blood CD4+ cell counts but not CD3+ and CD8+ cell counts are reduced in SARS-CoV-2 infection.

ABSTRACT:

Background

The world is facing the global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). T cell-induced immune responses during acute SARS-CoV-2 infection have rarely been reported.

Methods

We use cell counting chips and PCR arrays to offer the first insights into the T cell involved in the course of acute SARS-CoV-2 infection. All consecutive patients with suspected SARS-CoV-2 infection treated at the designated hospital between January 2020 and February 2020 were recruited for the study, and cases were confirmed by real-time RT-PCR. Baseline characteristics for inpatients were prospectively collected and analyzed.

Results

96 patients with suspected SARS-CoV-2 infection in our center were screened for inclusion in the study. The median ag

SUBMITTER: Huang ZX 

PROVIDER: S-EPMC7443336 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature