Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy.

ABSTRACT:

Objective

The aim of this study was to determine whether downstream [peroxisome proliferator-activated-receptor alpha (PPARα) and the G-protein coupled receptor, GPR119] and upstream (a fatty acid translocase, CD36) signaling targets of N-oleoylethanolamide (OEA) were necessary for weight loss, metabolic improvements, and diet preference following vertical sleeve gastrectomy (VSG).

Summary background data

OEA is an anorectic N-acylethanolamine produced from dietary fats within the intestinal lumen that can modulate lipid metabolism, insulin secretion, and energy expenditure by activating targets such as PPARα and GPR119.

Methods

Diet-induced obese mice, including wild-type or whole body knockout (KO) of PPARα, GPR119, and CD36, were stratified to either VSG or sham su

SUBMITTER: Hutch CR 

PROVIDER: S-EPMC7451489 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature