Ontology highlight
ABSTRACT:
SUBMITTER: Steiman TJ
PROVIDER: S-EPMC7457342 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20200406 16
A photoassisted Ni-catalyzed reductive cross-coupling between tosyl-protected alkyl aziridines and commercially available (hetero)aryl iodides is reported. This mild and modular method proceeds in the absence of stoichiometric heterogeneous reductants and uses an inexpensive organic photocatalyst to access medicinally valuable β-phenethylamine derivatives. Unprecedented reactivity was achieved with the activation of cyclic aziridines. Mechanistic studies suggest that the regioselectivity and rea ...[more]