Ontology highlight
ABSTRACT:
SUBMITTER: Lee M
PROVIDER: S-EPMC7459300 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Nature communications 20200831 1
Invariant natural killer T (iNKT), mucosal-associated invariant T (MAIT), and γδ T cells are innate T cells that acquire memory phenotype in the thymus and share similar biological characteristics. However, how their effector differentiation is developmentally regulated is still unclear. Here, we identify analogous effector subsets of these three innate T cell types in the thymus that share transcriptional profiles. Using single-cell RNA sequencing, we show that iNKT, MAIT and γδ T cells mature ...[more]