Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells.

ABSTRACT: Most T lymphocytes leave the thymus as naïve cells with limited functionality. However, unique populations of innate-like T cells differentiate into functionally distinct effector subsets during their development in the thymus. Here, we profiled >10,000 differentiating thymic invariant natural killer T (iNKT) cells using single-cell RNA sequencing to produce a comprehensive transcriptional landscape that highlights their maturation, function, and fate decisions at homeostasis. Our results reveal transcriptional profiles that are broadly shared between iNKT and mucosal-associated invariant T (MAIT) cells, illustrating a common core developmental program. We further unmask a mutual requirement for Hivep3, a zinc finger transcription factor and adapter protein. Hivep3 is expressed in early pr

SUBMITTER: Harsha Krovi S 

PROVIDER: S-EPMC7721697 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature