BMI1 promotes steroidogenesis through maintaining redox homeostasis in mouse MLTC-1 and primary Leydig cells.
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ABSTRACT:
SUBMITTER: Gao T
PROVIDER: S-EPMC7469621 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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BMI1 promotes steroidogenesis through maintaining redox homeostasis in mouse MLTC-1 and primary Leydig cells.
Gao Tingting T Lin Meng M Shao Binbin B Zhou Qiao Q Wang Yufeng Y Chen Xia X Zhao Dan D Dai Xiuliang X Shen Cong C Cheng Hongbo H Yang Shenmin S Li Hong H Zheng Bo B Zhong Xingming X Yu Jun J Chen Li L Huang Xiaoyan X
Cell cycle (Georgetown, Tex.) 20200628 15
In males, aging is accompanied by decline in serum testosterone levels due to impairment of testicular Leydig cells. The polycomb protein BMI1 has recently been identified as an anti-aging factor. In our previous study, BMI1 null mice showed decreased serum testosterone and Leydig cell population, excessive oxidative stress and p16/p19 signaling activation. However, a cause-and-effect relationship between phenotypes and pathways was not investigated. Here, we used the rescue approach to study th ...[more]
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