The role of estrogen receptor beta in breast cancer.

ABSTRACT: Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most common cancer among women worldwide. Challenges facing the diagnosis and treatment of breast cancer necessitate the search for new mechanisms and drugs to improve outcomes. Estrogen receptor (ER) is considered to be important for determining the diagnosis and treatment strategy. The discovery of the second estrogen receptor, ER?, provides an opportunity to understand estrogen action. The emergence of ER? can be traced back to 1996. Over the past 20?years, an increasing body of evidence has implicated the vital effect of ER? in breast cancer. Although there is controversy among scholars, ER? is generally thought to have antiproliferative effects in disease progression. This review summarizes available evidence regarding the involvement of ER? in the clinical treatment and prognosis of breast cancer and describes signaling pathways associated with ER?. We hope to highlight the potential of ER? as a therapeutic target.

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7487630 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature