The effect of combined carprofen and omeprazole administration on gastrointestinal permeability and inflammation in dogs.

ABSTRACT:

Background

Proton pump inhibitors (eg, omeprazole) commonly are administered concurrently with nonsteroidal anti-inflammatory drugs (NSAIDs; eg, carprofen) as prophylaxis to decrease the risk of gastrointestinal (GI) injury. However, evidence to support this practice is weak, and it might exacerbate dysbiosis and inflammation.

Hypothesis/objectives

To evaluate the effect of carprofen alone or combined with omeprazole in dogs. We hypothesized that coadministration of omeprazole and carprofen would significantly increase GI permeability and dysbiosis index (DI) compared to no treatment or carprofen alone.

Animals

Six healthy adult colony beagle dogs.

Methods

Gastrointestinal permeability and inflammation were assessed by serum lipopolysaccharide (LPS) concentrati

SUBMITTER: Jones SM 

PROVIDER: S-EPMC7517840 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature