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TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells.

ABSTRACT: In addition to Foxp3+ CD4+ regulatory T cells (CD4+ T reg cells), Foxp3- CD8+ regulatory T cells (CD8+ T reg cells) are critical to maintain immune tolerance. However, the molecular programs that specifically control CD8+ but not CD4+ T reg cells are largely unknown. Here, we demonstrate that simultaneous disruption of both TGF-β receptor and transcription factor Eomesodermin (Eomes) in T cells results in lethal autoimmunity due to a specific defect in CD8+ but not CD4+ T reg cells. Further, TGF-β signal maintains the regulatory identity, while Eomes controls the follicular location of CD8+ T reg cells. Both TGF-β signal and Eomes coordinate to promote the homeostasis of CD8+ T reg cells. Together, we have identified a unique molecular program designed for CD8+ T reg cells.

SUBMITTER: Mishra S

PROVIDER: S-EPMC7527976 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells.

Mishra Shruti S Liao Wei W Liu Yong Y Yang Ming M Ma Chaoyu C Wu Haijing H Zhao Ming M Zhang Xin X Qiu Yuanzheng Y Lu Qianjin Q Zhang Nu N

The Journal of experimental medicine 20210101 1

In addition to Foxp3+ CD4+ regulatory T cells (CD4+ T reg cells), Foxp3- CD8+ regulatory T cells (CD8+ T reg cells) are critical to maintain immune tolerance. However, the molecular programs that specifically control CD8+ but not CD4+ T reg cells are largely unknown. Here, we demonstrate that simultaneous disruption of both TGF-β receptor and transcription factor Eomesodermin (Eomes) in T cells results in lethal autoimmunity due to a specific defect in CD8+ but not CD4+ T reg cells. Further, TGF ...[more]

PMID: 32991667

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