High Levels of Eomes Promote Exhaustion of Anti-tumor CD8⁺ T Cells.

ABSTRACT: Eomes, a T-box transcription factor, is known important for both function and homeostasis of effector and memory T cells, but was recently also implicated in CD8⁺ T cell exhaustion. However, whether and how Eomes might regulate effector functions or exhaustion of CD8⁺ T cells, especially in the tumor setting, is unknown. Here we first show, as tumor progressed, Eomes expression was elevated in tumor-infiltrating CD8⁺ T cells, especially in PD-1⁺Tim-3⁺ exhausted CD8⁺ T cells. Complete loss of Eomes in T cells resulted in impaired development of anti-tumor CTLs, whereas deletion of one allele of Eomes in T cells decreased development of exhausted CD8⁺ T cells, which offered better tumor control. Integrative a

SUBMITTER: Li J 

PROVIDER: S-EPMC6305494 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature