The transcription factor IRF2 drives interferon-mediated CD8⁺ T cell exhaustion to restrict anti-tumor immunity.

ABSTRACT: Type I and II interferons (IFNs) stimulate pro-inflammatory programs that are critical for immune activation, but also induce immune-suppressive feedback circuits that impede control of cancer growth. Here, we sought to determine how these opposing programs are differentially induced. We demonstrated that the transcription factor interferon regulatory factor 2 (IRF2) was expressed by many immune cells in the tumor in response to sustained IFN signaling. CD8⁺ T cell-specific deletion of IRF2 prevented acquisition of the T cell exhaustion program within the tumor and instead enabled sustained effector functions that promoted long-term tumor control and increased responsiveness to immune checkpoint and adoptive cell therapies. The long-term tumor control by IRF2-deficient CD8⁺

SUBMITTER: Lukhele S 

PROVIDER: S-EPMC9809269 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature