In Vivo Neuroelectrophysiological Monitoring of Atomically Precise Au₂₅ Clusters at an Ultrahigh Injected Dose.

ABSTRACT: Atomically precise Au₂₅(SG)₁₈ clusters have shown great promise in near-infrared II cerebrovascular imaging, X-ray imaging, and cancer radiotherapy due to their high atomic number, unique molecular-like electronic structure, and renal clearable properties. Therefore, it is important to study the in vivo toxicity of Au₂₅ clusters. Unfortunately, previous toxicological investigations focused on low injected doses (<100 mg kg^-1) and routine research methods, such as blood chemistry and biochemistry, which cannot reflect neurotoxicity or tiny changes in neural activity. In this work, in vivo neuroelectrophysiology of Au₂₅ clusters at ultrahigh injected doses (200, 300, and 500 mg kg^-1) was investigated. Local field potential sho

SUBMITTER: Hao W 

PROVIDER: S-EPMC7528291 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature