Δ⁹-Tetrahydrocannabinol (THC) Impairs CD8⁺ T Cell-Mediated Activation of Astrocytes.

ABSTRACT: CD8⁺ T cells can contribute to neuroinflammation by secretion of inflammatory cytokines like interferon γ (IFNγ) and tumor necrosis factor α (TNFα). Astrocytes, a glial cell in the brain, can be stimulated by IFNγ and TNFα to secrete the inflammatory cytokines, monocyte chemotactic protein 1 (MCP-1), interleukin 6 (IL-6), and interferon-γ inducible protein 10 (IP-10). Δ⁹-Tetrahydrocannabinol (THC), the primary psychoactive cannabinoid in Cannabis sativa, possesses potent anti-inflammatory activity. The objective of this investigation was to assess the effects of THC treatment on CD8⁺ T cell-mediated activation of astrocytes. CD3/CD28/IFNα- stimulated CD8⁺ T cells were treated with vehicle (0.03% EtOH) or THC and cocultured with U251 astrocytes. I

SUBMITTER: Henriquez JE 

PROVIDER: S-EPMC7529688 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature