Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study.

ABSTRACT:

Objective

To determine the joint role of ideal cardiovascular health (CVH) and genetic risk on risk of dementia.

Methods

We categorized CVH on the basis of the American Heart Association Ideal CVH Index and genetic risk through a genetic risk score (GRS) of common genetic variants and the APOE ε4 genotype in 1,211 Framingham Heart Study (FHS) offspring cohort participants. We used multivariable Cox proportional hazards regression models to examine the association between CVH, genetic risk, and incident all-cause dementia with up to 10 years of follow-up (mean 8.4 years, 96 incident dementia cases), adjusting for age, sex, and education.

Results

We observed that a high GRS (>80th percentile) was associated with a 2.6-fold risk of dementia (95% confidence interva

SUBMITTER: Peloso GM 

PROVIDER: S-EPMC7538213 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature