Brain Network Connectivity and Association with Catechol-O-Methyltransferase Gene Polymorphism in Korean Attention-Deficit Hyperactivity Disorder Children.

ABSTRACT:

Objective

We sought to determine if the links between and within the default mode network (DMN) and dorsal attention network (DAT) exhibited different conditions according to catechol-O-methyltransferase (COMT) gene polymorphism in relationship to attention-deficit hyperactivity disorder (ADHD) symptoms.

Methods

Fifty-seven children with ADHD and 48 healthy controls (HCs) were administered an intelligence test, the Children's Depression Inventory, the Korean ADHD rating scale, and continuous performance test. Resting-state brain functional MRI scans were obtained, and COMT genotyping was performed to distinguish valine carriers and methionine homozygotes.

Results

Compared to controls, children with ADHD showed increased ADHD scale scores, increased visual commission e

SUBMITTER: Park JH 

PROVIDER: S-EPMC7538244 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature