The effect of civil and military flights on coagulation, fibrinolysis and blood flow: insight from a rat model.

ABSTRACT:

Background

Air travel thrombosis continues to be a controversial topic. Exposure to hypoxia and hypobaric conditions during air travel is assumed a risk factor. The aim of this study is to explore changes in parameters of coagulation, fibrinolysis and blood flow in a rat model of exposure to hypobaric conditions that imitate commercial and combat flights.

Methods

Sixty Sprague-Dawley male rats, aged 10 weeks, were divided into 5 groups according to the type and duration of exposure to hypobaric conditions. The exposure conditions were 609 m and 7620 m for 2 and 12 h duration. Blood count, thrombin- antithrombin complex, D-dimer, interleukin-1 and interleukin-6 were analyzed. All rats went through flight angiography MRI at day 13-post exposure.

Results

No effect of the

SUBMITTER: Levkovsky A 

PROVIDER: S-EPMC7541254 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature