Dataset Information

The effect of civil and military flights on coagulation, fibrinolysis and blood flow: insight from a rat model.

ABSTRACT:

Background

Air travel thrombosis continues to be a controversial topic. Exposure to hypoxia and hypobaric conditions during air travel is assumed a risk factor. The aim of this study is to explore changes in parameters of coagulation, fibrinolysis and blood flow in a rat model of exposure to hypobaric conditions that imitate commercial and combat flights.

Methods

Sixty Sprague-Dawley male rats, aged 10 weeks, were divided into 5 groups according to the type and duration of exposure to hypobaric conditions. The exposure conditions were 609 m and 7620 m for 2 and 12 h duration. Blood count, thrombin- antithrombin complex, D-dimer, interleukin-1 and interleukin-6 were analyzed. All rats went through flight angiography MRI at day 13-post exposure.

Results

No effect of the various exposure conditions was observed on coagulation, fibrinolytic system, IL-1 or IL-6. MRI angiography showed blood flow reduction in lower limb to less than 30% in 50% of the rats. The reduction in blood flow was more pronounced in the left vessel than in the right vessel (p = 0.006, Wilcoxon signed rank test). The extent of occlusion differed across exposure groups in the right, but not the left vessel (p = 0.002, p = 0.150, respectively, Kruskal-Wallis test). However, these differences did not correlate with the exposure conditions.

Conclusion

In the present rat model, no clear correlation between various hypobaric conditions and activation of coagulation was observed. The reduction in blood flow in the lower limb also occurred in the control group and was not related to the type of exposure.

SUBMITTER: Levkovsky A

PROVIDER: S-EPMC7541254 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

The effect of civil and military flights on coagulation, fibrinolysis and blood flow: insight from a rat model.

Levkovsky Anna A Dardik Rima R Barazany Daniel D Steinberg David M DM Kirichenko Mark Dan MD Apter Sara S Peleg Edna E Silverberg Daniel D Grossman Ehud E Salomon Ophira O

Thrombosis journal 20201006

<h4>Background</h4>Air travel thrombosis continues to be a controversial topic. Exposure to hypoxia and hypobaric conditions during air travel is assumed a risk factor. The aim of this study is to explore changes in parameters of coagulation, fibrinolysis and blood flow in a rat model of exposure to hypobaric conditions that imitate commercial and combat flights.<h4>Methods</h4>Sixty Sprague-Dawley male rats, aged 10 weeks, were divided into 5 groups according to the type and duration of exposur ...[more]

PMID: 33041672

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Dataset Information

The effect of civil and military flights on coagulation, fibrinolysis and blood flow: insight from a rat model.

Background

Methods

Results

Conclusion

Publications

The effect of civil and military flights on coagulation, fibrinolysis and blood flow: insight from a rat model.

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