The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease.
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ABSTRACT:
SUBMITTER: Peischard S
PROVIDER: S-EPMC7546621 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease.
Peischard Stefan S Ho Huyen Tran HT Piccini Ilaria I Strutz-Seebohm Nathalie N Röpke Albrecht A Liashkovich Ivan I Gosain Hiteshika H Rieger Bettina B Klingel Karin K Eggers Britta B Marcus Katrin K Linke Wolfgang A WA Müller Frank Ulrich FU Ludwig Stephan S Greber Boris B Busch Karin K Seebohm Guiscard G
Scientific reports 20201008 1
A detailed description of pathophysiological effects that viruses exert on their host is still challenging. For the first time, we report a highly controllable viral expression model based on an iPS-cell line from a healthy human donor. The established viral model system enables a dose-dependent and highly localized RNA-virus expression in a fully controllable environment, giving rise for new applications for the scientific community. ...[more]
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