IL-13 as Target to Reduce Cholestasis and Dysbiosis in Abcb4 Knockout Mice.

ABSTRACT: The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in an Abcb4-knockout mouse model (Abcb4^-/-). Lack of IL-13 protected Abcb4^-/- mice transiently from cholestasis. This decrease in serum bile acids was accompanied by an enhanced excretion of bile acids and a normalization of fecal bile acid composition. In Abcb4^-/-/IL-13^-/- double knockout mice, bacterial translocation to the liver was significantly reduced and the intestinal microbiome resembled the commensal composition in wild type animals. In addition, 52-week-old Ab

SUBMITTER: Hahn L 

PROVIDER: S-EPMC7564366 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature