Dynamic Expression Profiles of β-Catenin during Murine Cardiac Valve Development.

ABSTRACT: β-catenin has been widely studied in many animal and organ systems across evolution, and gain or loss of function has been linked to a number of human diseases. Yet fundamental knowledge regarding its protein expression and localization remains poorly described. Thus, we sought to define whether there was a temporal and cell-specific regulation of β-catenin activities that correlate with distinct cardiac morphological events. Our findings indicate that activated nuclear β-catenin is primarily evident early in gestation. As development proceeds, nuclear β-catenin is down-regulated and becomes restricted to the membrane in a subset of cardiac progenitor cells. After birth, little β-catenin is detected in the heart. The co-expression of β-catenin with its main transcriptional co-factor, Lef1,

SUBMITTER: Guo L 

PROVIDER: S-EPMC7570242 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature