Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19.

ABSTRACT:

Purpose

The coronavirus disease 2019 (COVID-19) pandemic severely challenges public health and necessitates the need for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and propagation. The aim of this study was to investigate key factors for cellular susceptibility to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection in the ocular surface cells.

Methods

We combined co-expression and SARS-CoV-2 interactome network to predict key genes at COVID-19 in ocular infection based on the premise that genes underlying a disease are often functionally related and functionally related genes are often co-expressed.

Results

The co-expression network was constructed by mapping the well-known angiotensin

SUBMITTER: Yuan J 

PROVIDER: S-EPMC7571327 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature