Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.

ABSTRACT:

Importance

Compared with non-Hispanic White individuals, African American individuals from the same community are approximately twice as likely to develop Alzheimer disease. Despite this disparity, the largest Alzheimer disease genome-wide association studies to date have been conducted in non-Hispanic White individuals. In the largest association analyses of Alzheimer disease in African American individuals, ABCA7, TREM2, and an intergenic locus at 5q35 were previously implicated.

Objective

To identify additional risk loci in African American individuals by increasing the sample size and using the African Genome Resource panel.

Design, setting, and participants

This genome-wide association meta-analysis used case-control and family-based data sets from the Alzheimer

SUBMITTER: Kunkle BW 

PROVIDER: S-EPMC7573798 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature