Emergence of T cell immunosenescence in diabetic chronic kidney disease.

ABSTRACT:

Background

Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries. It is known that patients with ESRD and advanced renal failure suffer from immunosenescence and premature T cell aging, but whether such changes develop in patients with less severe chronic kidney disease (CKD) is unclear.

Method

523 adult patients with type 2 diabetes were recruited for this study. Demographic data and clinical information were obtained from medical chart review. Immunosenescence, or aging of the immune system was assessed by staining freshly-obtained peripheral blood with immunophenotyping panels and analyzing cells using multicolor flow cytometry.

Result

Consistent with previousl

SUBMITTER: Chiu YL 

PROVIDER: S-EPMC7574244 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature