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Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development.

ABSTRACT: Thalamus is a critical information relay hub in the cortex; its malfunction causes multiple neurological and psychiatric disorders. However, there are no model systems to study the development and function of human thalamus. Here, we present a protocol to generate regionally specified human brain organoids that recapitulate the development of the thalamus using human pluripotent stem cells (hPSCs). Thalamic organoids can be used to study human thalamus development, to model related diseases, and to discover potential therapeutics. For complete information on human thalamic organoids and their application, please refer to the paper by Xiang et al. (2019).

SUBMITTER: Xiang Y

PROVIDER: S-EPMC7580078 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development.

Xiang Yangfei Y Cakir Bilal B Park In-Hyun IH

STAR protocols 20200604 1

Thalamus is a critical information relay hub in the cortex; its malfunction causes multiple neurological and psychiatric disorders. However, there are no model systems to study the development and function of human thalamus. Here, we present a protocol to generate regionally specified human brain organoids that recapitulate the development of the thalamus using human pluripotent stem cells (hPSCs). Thalamic organoids can be used to study human thalamus development, to model related diseases, and ...[more]

PMID: 33103124

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