A proof-of principal study using phase-contrast imaging for the detection of large airway pathologies after lung transplantation.

ABSTRACT: In this study we aim to evaluate the assessment of bronchial pathologies in a murine model of lung transplantation with grating-based X-ray interferometry in vivo. Imaging was performed using a dedicated grating-based small-animal X-ray dark-field and phase-contrast scanner. While the contrast modality of the dark-field signal already showed several promising applications for diagnosing various types of pulmonary diseases, the phase-shifting contrast mechanism of the phase contrast has not yet been evaluated in vivo. For this purpose, qualitative analysis of phase-contrast images was performed and revealed pathologies due to previous lung transplantation, such as unilateral bronchial stenosis or bronchial truncation. Dependent lung parenchyma showed a strong loss in dark-field and absorpti

SUBMITTER: Umkehrer S 

PROVIDER: S-EPMC7595203 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature