Clustering analysis of large-scale phenotypic data in the model filamentous fungus Neurospora crassa.

ABSTRACT:

Background

With 9730 protein-coding genes and a nearly complete gene knockout strain collection, Neurospora crassa is a major model organism for filamentous fungi. Despite this abundance of information, the phenotypes of these gene knockout mutants have not been categorized to determine whether there are broad correlations between phenotype and any genetic features.

Results

Here, we analyze data for 10 different growth or developmental phenotypes that have been obtained for 1168 N. crassa knockout mutants. Of these mutants, 265 (23%) are in the normal range, while 903 (77%) possess at least one mutant phenotype. With the exception of unclassified functions, the distribution of functional categories for genes in the mutant dataset mirrors that of the N. crassa genome. In cont

SUBMITTER: Carrillo AJ 

PROVIDER: S-EPMC7607824 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature