CD-1^db/db mice: A novel type 2 diabetic mouse model with progressive kidney fibrosis.

ABSTRACT:

Aims/introduction

To establish novel therapies to combat diabetic kidney disease, a human disease-relevant animal model is essential. However, a type 2 diabetic mouse model presenting progressive kidney fibrosis has not yet been established. Kidneys of streptozotocin-induced diabetic CD-1 mice showed severe fibrosis compared with other backgrounds of mice associated with the suppression of antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline. The BKS background (BKS^{db / db} ) is often utilized for diabetic kidney disease research; the kidney fibrosis in the BKS^{db / db} phenotype is minimal.

Materials and methods

We generated CD-1^{db / db} mice by backcrossing the db gene into

SUBMITTER: Mizunuma Y 

PROVIDER: S-EPMC7610117 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature