Monomeric TCRs drive T cell antigen recognition.
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ABSTRACT:
SUBMITTER: Brameshuber M
PROVIDER: S-EPMC7612939 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Monomeric TCRs drive T cell antigen recognition.
Brameshuber Mario M Kellner Florian F Rossboth Benedikt K BK Ta Haisen H Alge Kevin K Sevcsik Eva E Göhring Janett J Axmann Markus M Baumgart Florian F Gascoigne Nicholas R J NRJ Davis Simon J SJ Stockinger Hannes H Schütz Gerhard J GJ Huppa Johannes B JB
Nature immunology 20180416 5
T cell antigen recognition requires T cell antigen receptors (TCRs) engaging MHC-embedded antigenic peptides (pMHCs) within the contact region of a T cell with its conjugated antigen-presenting cell. Despite micromolar TCR:pMHC affinities, T cells respond to even a single antigenic pMHC, and higher-order TCRs have been postulated to maintain high antigen sensitivity and trigger signaling. We interrogated the stoichiometry of TCRs and their associated CD3 subunits on the surface of living T cells ...[more]
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2024-10-11 | GSE234359 | GEO