Circulating vitamin C and digestive system cancers: Mendelian randomization study.

ABSTRACT:

Background & aims

Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to utilize Mendelian randomization to decipher the potential causal associations of vitamin C with risk of digestive system cancers.

Methods

Ten genetic variants previously found to be significantly associated with circulating vitamin C were used as instrumental variables. Effect size estimates for the genetic associations of the vitamin C-associated genetic variants with six major malignancies of digestive system were obtained from the FinnGen (N = 309 154) and UK Biobank (N = 367 542) studies. Results from the two studies were combined using meta-analy

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC7613472 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature