Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia.

ABSTRACT:

Introduction

We tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD).

Methods

For hypothesis generation, 36 participants with behavioral variant FTD (bvFTD) and 34 controls were recruited from one site. For hypothesis testing, we studied 198 symptomatic FTD mutation carriers, 341 presymptomatic mutation carriers, and 329 family members without mutations. We compared functional network dynamics between groups, with clinical severity and with longitudinal clinical progression.

Results

We identified a characteristic pattern of dynamic network changes in FTD, which correlated with neuropsychological impairment. Among presymptomatic mutation c

SUBMITTER: Whiteside DJ 

PROVIDER: S-EPMC7614527 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature