Molecular Genetic Studies of Pancreatic Neuroendocrine Tumors: New Therapeutic Approaches.
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SUBMITTER: Stevenson M
PROVIDER: S-EPMC7614857 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
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Molecular Genetic Studies of Pancreatic Neuroendocrine Tumors: New Therapeutic Approaches.
Stevenson Mark M Lines Kate E KE Thakker Rajesh V RV
Endocrinology and metabolism clinics of North America 20180901 3
Pancreatic neuroendocrine tumors (PNETs) arise sporadically or as part of familial syndromes. Genetic studies of hereditary syndromes and whole exome sequencing analysis of sporadic NETs have revealed the roles of some genes involved in PNET tumorigenesis. The multiple endocrine neoplasia type 1 (MEN1) gene is most commonly mutated. Its encoded protein, menin, has roles in transcriptional regulation, genome stability, DNA repair, protein degradation, cell motility and adhesion, microRNA biogenes ...[more]
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