Ontology highlight
ABSTRACT:
SUBMITTER: Tirosh A
PROVIDER: S-EPMC7340809 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Journal of gastrointestinal oncology 20200601 3
Neuroendocrine tumors (NETs) are a heterogenous group of tumors that originate from neuroendocrine cells, mainly in the pancreas and the gastrointestinal and bronchopulmonary tracts. There has been considerable progress in our understanding of the genetic and epigenetic changes associated with pancreatic NETs (PNETs). The main genetic alterations that drive PNETs include genetic alterations in <i>MEN1</i>, <i>VHL</i> and genes involved in the mTOR pathway, <i>DAXX</i> and/or <i>ATRX</i> mutation ...[more]